To compare outcomes of stroke patients receiving GA and CS/local anesthesia during the procedure.
This meta-analysis showed that patients who received GA had lower rates of good functional outcome (mRs≤2; OR, 0.58; 95% confidence interval [CI], 0.48–0.64), higher rates of 90-days mortality (OR, 2.02; 95% CI, 1.66–2.45) and respiratory complications (OR, 1.70; 95% CI, 1.22–2.37) than patients who received CS. No difference in recanalization rates (OR, 1.04; 95% CI, 0.83–1.31) or vascular complications(OR, 1.43; 95% CI, 1.01–2.03) were found.
Authors also analyzed factors that might be associated with poorer neurological outcomes:
- Despite this meta-analysis showed that acute stroke patients receiving GA had significantly higher rates of morbidity and mortality compared with non-GA patients, the majority of published studies are not randomized trials. For this reason, additional randomized controlled trials are needed.
- Waleed Brinjikji, Jeffrey Pasternak, Mohammad H. Murad, Harry J. Cloft, Tasha L. Welch, David F. Kallmes, Alejandro A. Rabinstein. Anesthesia-related outcomes for endovascular stroke revascularization: a systematic review and meta-analysis. Stroke. 2017 Sep 13. pii: STROKEAHA.117.017786. doi: 10.1161/STROKEAHA.117.017786. [Epub ahead of print]